Relora side effects, cortisol, stress, blood pressure. AayurMed Biotech Pvt. D I felt - yes, idiot that I am - I felt degraded.
Then: Which room did you put her into? Was it dry? Is she up? Go and ask if she wants anything; and when she will come down. Three times a day she studied a little book, which I found, on inspection, was a Common Prayer Book. AayurMed Biotech officinalis research paper Pvt. After staining with hematoxylin and eosin for evaluation of vascular density and intravascular area, the Motic Image Plus2 software was served to measure the quantitative vascular parameters. A list of mouse primers utilized in this study was depicted in Table 1.
The results of the histological parameters of ovarian angiogenesis revealed a significant difference in the vascular parameters between the two groups at the preimplantation time. Vascular density of the test group Also, an intravascular area of the test group Histological morphology was also indicative of increased vascular sections in the test group compared to the control group.
Vascular sections were specially seen around and inside the corpus luteum and also were seen around the primary and secondary follicles. Histological data were depicted in Table 3 and Figure 2. Results of gene expression analysis of these genes were shown in Figure 3. Histological findings of our study demonstrated a significant difference in the vascular density and also intravascular area of an ovarian tissue between the two groups.
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It was concluded that the ethanolic extract of the leaves of S. Researchers showed that the ethanolic extract of S. Also, other researchers indicated an antiangiogenic activity of S. Over the recent studies, more attention has been focused on the antiangiogenic and antimetastatic effects of compounds from S. However, the results of the present study showed that the ethanolic extract of S.
These reports are in contradiction with the results of other studies, which have shown the anti-angiogenic activity of S. Antiangiogenic components of the S. The current study showed that the gene expression following S. It was also revealed that progesterone treatment after ovarian induction led to an increase in the VEGF gene expression and its receptors at the preimplantation time Considered together, it may be a biological activity of S. Phenolic diterpenes such as carnosol and carnosic acids were determined in the HPLC analysis of the ethanolic extract of S.
The mechanism of anti-inflammatory compounds mentioned above is as same as nonsteroidal anti-inflammatory drugs NSAIDS causing prostaglandin inhibition and resulting in increased corpus luteum, which leads to maintenance of pregnancy Therefore, it seems that some phytoestrogenic agents of S. There are several mechanisms involved in the upregulation of the VEGF gene expression and its receptors.
It is mentioned that hypoxia via hypoxia inducing factor, cytokine and growth factors such as interleukin-6 and the presence of some bioactive molecules in the ascite fluid upregulate VEGF gene expression 4. Other researchers indicated that HCG is as the prime mediator causing an increase in the VEGF gene expression containing some hypophyseal hormones involved in ovarian angiogenesis The results of the present study showed that administration of the ethanolic extract of S.
It may be related to ovarian hormone changes after S. The presence of the HCG receptor on microvascular endothelial cells as the primary target of HCG resulting in an acute release of VEGF, consequently can affect the KDR expression and finally a significant increase will happen in cytokines in an autocrine-paracrine outcome, which may increase vascular permeability It was declared that increased VEGF may induce vascular permeability but it may not be directly involved in the massive fluid transport as in severe OHSS 2.
In the present study, we did not observe a massive fluid transport although increased VEGF gene expression in the ovarian tissue may be associated with vascular permeability. Another study demonstrated that granulosa lutein cells and endothelial cells, which are sources of the VEGF production, may be involved in OHSS development Therefore, changes in ovarian angiogenesis can be considered as one of the adverse effects of using ethanolic extract of S. An adverse effect of the sage oil reported in a newborn and a child causing seizures after even a single ingested dose of S.
In addition, it is well-known that LH is an activator of adenylate cyclase and acts as a stimulator on ovarian angiogenesis in the granulosa cells of primate More importantly, luteinized granulosa and thecal cells express VEGF at early pregnancy. Thus, overincitement of the VEGF expression is created by an increased level of gonadotropin and ovarian hormones 36 , So, regarding the effect of the ethanolic extract of S. In conclusion, herbs may have an unrecognized effect on pregnancy and serious complication on the fetus.
Natural plants products have been used since ancient times and are now increasing. In fact, different tissues have diverse responses of stromal cells in each tissue depending on the number of cell surface receptors on these cells. Ovarian tissue is no exception.
Each of these stromal cells could directly or indirectly affect the microenviroment tissue, which itself could change the vascular gene expression. Increased ovarian angiogenesis after the S. To provide the best care to a pregnant woman who uses herbal products, we recommend that scientists stay up to date with their safety in pregnancy. Further research is needed to elucidate the potential and beneficial role of the responsible component of S.
The antiangiogenic activities of ethanolic crude extracts of four Salvia species. Ajonuma LC. Med Hypotheses. Vascular endothelial growth factor receptor-2 activation induces vascular permeability in hyperstimulated rats, and this effect is prevented by receptor blockade. Geva E, Jaffe RB. Role of vascular endothelial growth factor in ovarian physiology and pathology. Due to its volatile organic compounds and active constituents such as terpenoids, flavonoids, quercetin, rutin, quercitrin, gallic acid and high antioxidant capacity, the extract of the plant can have a significant role in maintaining health and curing diseases.
Search in the interval of the years to was carried out. To search for the key words Melissa officinalis , lemon balm, and balm mint were used. About 80 articles was reviewed and after rejection non-related or similar items, in the end about 50 the number was actually cited. Results indicate that the extract of the plant with its several antioxidant, anti- inflammatory, anti-pain, anti-spasmodic and anti-cancer properties as well as its cholinergic receptor activation have highly significant effects on improving behavioral symptoms, cognitive impairment, insomnia, anxiety, and stress.
However, these studies have been vast and sparse, and doing more focused and extensive researches in this area is recommended. Lipids Liver Antioxidants.
Antioxidant Activity of Flavonoids Isolated from Rosmarinus officinalis L.
Medicinal plants have had a great role in providing health and treatment as well as disease prevention in human communities [ 1 , 2 ]. Medicinal herbs are very rich in secondary metabolites which have profound physiological effects on the function of mammalian tissues in health and disease conditions [ 3 , 4 ]. Melissa officinalis lemon balm is one of these known herbs that has been used since a very long time ago for the treatment of many illnesses like headaches, gastrointestinal diseases, neurological diseases and rheumatoid [ 5 , 6 ].
It is also cultivated worldwide for its edible properties [ 7 - 9 ]. This herb has been used extensively in traditional medicine and the history of it goes back to more than 2, years ago.
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The plant has been used in a variety of ways from a sedative and mild hypnotic drug , and reducing the heart rate, antibacterial, antiinflammatory, antivirus, antispasmodic, antioxidant, to a neurotherapeutic agent, peripheral analgesic, as well as a binding agent to cholinergic receptors [ 7 - 11 ]. Avicenna, the Iranian eminent physician and philosopher introduced this plant as vitality tonic and as a sedative drug to treat neurological disorders [ 11 ].
The most important ingredients in the plant are known to be phenolic compounds, rosmarinic acid, caffeic acid, cholinergic acid, metrilic acid; flavonoids such as luteolin, apigenin and monoterpene derivatives; the sesquiterpenes including beta-caryophyllene and germacrene; triterpenes such as oleanolic and ursolic acid; volatile oil, and tannins [ 8 ]. The aim of present article is to give a brief overview of the health benefits of M.
This review article is a survey of the empirical papers of several authors who have examined the role of M. To search for the key words M. The effect of M.
Officinalis research paper
Among effective pharmacological agents in treating these diseases, we can refer to statins, clofibrates and niacin. However, in general these compounds are not effective in reducing cholesterol concentration and are often associated with adverse effects and drug toleration, [ 12 - 19 ]. Therefore, all efforts have been concentrated on prevention strategies like phytochemical diet.
According to recent studies, M. Terpenoids are among the essential compounds in herbal oils that induce hypolipidemic effects by inhibiting liver biosynthesis and formation of cholesterol nucleus in bile. Although the lipid-lowering mechanism of M. In addition, M. Evidence show that herbal oils, including M.
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In a study on rats with hypercholesterolaemia, Changizi-Ashtiyani et al. However, the hypolipidemic properties of alcoholic extract of M. Jun et al. Study of Zarei et al. Various reasons have been proposed for the increase in liver enzymes in hypercholesterolemic rats. For example one theory says that the accumulation of lipids in the liver raises a pathological state causing fibrous changes and eventually cirrhosis and hepatic dysfunction.
Following these disorders, levels of liver enzymes, particularly ALT increases [ 24 ]. On the other hand, hyperlipidemia will also stimulate the production of free radicals [ 25 ].
The impact of M. This plant contains phenolic compounds, which are among the most important antioxidant agents. These compounds, especially flavonoids have a protective effect on liver against damages caused by free radicals because of their inhibitory effect on the cytochrome system.